Detalhe da pesquisa
1.
Evolution of Partial Resistance to Artemisinins in Malaria Parasites in Uganda.
N Engl J Med
; 389(8): 722-732, 2023 Aug 24.
Artigo
Inglês
| MEDLINE | ID: mdl-37611122
2.
Ex vivo drug susceptibility and resistance mediating genetic polymorphisms of Plasmodium falciparum in Bobo-Dioulasso, Burkina Faso.
Antimicrob Agents Chemother
; 68(4): e0153423, 2024 Apr 03.
Artigo
Inglês
| MEDLINE | ID: mdl-38411062
3.
Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates.
J Infect Dis
; 225(4): 696-704, 2022 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34460932
4.
Impact of Short-Term Storage on Ex Vivo Antimalarial Susceptibilities of Fresh Ugandan Plasmodium falciparum Isolates.
Antimicrob Agents Chemother
; 66(4): e0143721, 2022 04 19.
Artigo
Inglês
| MEDLINE | ID: mdl-35266828
5.
Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors.
Antimicrob Agents Chemother
; 66(10): e0081722, 2022 10 18.
Artigo
Inglês
| MEDLINE | ID: mdl-36094216
6.
Changing Prevalence of Potential Mediators of Aminoquinoline, Antifolate, and Artemisinin Resistance Across Uganda.
J Infect Dis
; 223(6): 985-994, 2021 03 29.
Artigo
Inglês
| MEDLINE | ID: mdl-33146722
7.
Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates.
Antimicrob Agents Chemother
; 65(10): e0077121, 2021 09 17.
Artigo
Inglês
| MEDLINE | ID: mdl-34339273
8.
Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum.
Malar J
; 20(1): 292, 2021 Jun 30.
Artigo
Inglês
| MEDLINE | ID: mdl-34193148
9.
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.
Proc Natl Acad Sci U S A
; 115(29): E6863-E6870, 2018 07 17.
Artigo
Inglês
| MEDLINE | ID: mdl-29967165
10.
Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice.
Angew Chem Int Ed Engl
; 60(17): 9279-9283, 2021 04 19.
Artigo
Inglês
| MEDLINE | ID: mdl-33433953
11.
Changing Antimalarial Drug Sensitivities in Uganda.
Antimicrob Agents Chemother
; 61(12)2017 12.
Artigo
Inglês
| MEDLINE | ID: mdl-28923866
12.
Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays.
Antimicrob Agents Chemother
; 59(8): 5061-4, 2015 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-26033725
13.
Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children.
Antimicrob Agents Chemother
; 59(6): 3018-30, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25753626
14.
Discovery of dual function acridones as a new antimalarial chemotype.
Nature
; 459(7244): 270-3, 2009 May 14.
Artigo
Inglês
| MEDLINE | ID: mdl-19357645
15.
Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases.
J Med Chem
; 67(2): 1460-1480, 2024 Jan 25.
Artigo
Inglês
| MEDLINE | ID: mdl-38214254
16.
Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline.
Microbiol Spectr
; 11(3): e0523622, 2023 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37158739
17.
Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome InhibitorsâPart II.
J Med Chem
; 66(2): 1484-1508, 2023 01 26.
Artigo
Inglês
| MEDLINE | ID: mdl-36630286
18.
Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial cinchona alkaloids.
Antimicrob Agents Chemother
; 56(10): 5356-64, 2012 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-22869567
19.
Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda.
Nat Commun
; 13(1): 6353, 2022 10 26.
Artigo
Inglês
| MEDLINE | ID: mdl-36289202
20.
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.
Nat Commun
; 13(1): 2158, 2022 04 20.
Artigo
Inglês
| MEDLINE | ID: mdl-35444200